Liverpool vs Atletico Madrid prediction and tips: Alexander Isak 11/10 to score again

Anfield The home stadium of Liverpool FC
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Liverpool welcome Atletico Madrid to Anfield boosted by their first competitive win under Andoni Iraola and looking to continue their recent dominance over the Spanish side. The Reds started their Premier League campaign with virtually identical 2-2 draws against Newcastle and Nottingham Forest before picking up three points against promoted Ipswich on Friday.

Liverpool vs Atletico Madrid Prediction - Champions League 2026-27

They will now seek to build on that with victory when facing Atletico in their Champions League opener, and history suggests it could be a good night for Reds fans. Liverpool have won three successive matches against Atletico , including a 3-2 thriller 12 months ago when Virgil van Dijk netted a stoppage-time winner at Anfield .

On top of that, Atletico have only won two of their last 14 meetings with English teams and have never won a Champions League group/league phase match against a Premier League outfit. We think that winless run will continue on Wednesday, with our initial Liverpool vs Atletico Madrid prediction being a home victory with BTTS @ 2/1.

2/1
● LIVE ODDS Liverpool Both Teams To Score And Match Result

Betting Odds

Liverpool vs Atletico Madrid Betting Odds – Champions League 2026-27

Result

Odds

Chance

Liverpool

8/13

61.9%

Atletico Madrid

16/5

23.8%

Draw

14/5

26.3%

*Odds are correct at the time of writing, but subject to change.

Liverpool are 8/13 favourites to beat Atletico Madrid , who are 16/5 for the win, with the draw at 14/5.

How to Watch

How to watch Liverpool vs Atletico Madrid

The Champions League league-stage match is scheduled to begin at 20:00 BST on Wednesday and will be shown live on TNT Sports 1.

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Champions League Prediction - 2026-27 season

Form Guides

Liverpool form guide

Alexander Isak’s early brace against Ipswich ensured three points for Liverpool at Portman Road and a much more comfortable outing than their first two under new boss Iraola . Liverpool trailed twice against Newcastle and Forest and required late equalisers from Dominik Szoboszlai and Victor Munoz to avoid defeats.

They now turn their attention to the Champions League , where the six-time European champions have proven masters of the new format, claiming 13 victories in 16 matches en route to finishing first and third in the league phase.

They have not managed to progress much further than that however, falling at the last 16 and quarter-final stages, and they are not among the favourites to go all the way this time either. However, if Isak can rediscover the goalscoring form that led Liverpool to splash out a club-record £125million to sign him from Newcastle last summer, then the Reds cannot be written off.

Isak scored just five goals during an injury-hit first season on Merseyside but the Sweden striker has now struck three times in his last two games, and 11/10 to notch against Atletico . We also fancy big-money new signing Bradley Barcola, a two-time Champions League winner with Paris St Germain, to mark his Anfield debut with a goal @ 15/8.

11/10
● LIVE ODDS Alexander Isak Anytime Goalscorer

Atletico Madrid form guide

Atletico reached the Champions League semi-finals and Copa del Rey final last season but their league campaign was a different story. They finished a massive 25 points behind champions Barcelona in fourth place and their 11 defeats were the most they had suffered in a single campaign since 2012.

That came after a poor start which saw them win only one of their opening six games - including that 3-2 loss at Liverpool - but Diego Simeone’s men have enjoyed a better return this season. Atleti picked up seven points from a tricky-looking fixture list against Malaga , Villarreal and Sevilla before suffering 3-0 loss at Athletic Bilbao on Saturday.

That was hardly the best preparation for Wednesday’s trip to Anfield but Simeone will undoubtedly have his players back up for the fight. You can get 4/7 for both teams to score, while Spain World Cup-winner Alex Baena could be a decent bet to find the back of the net for the fourth time this season @ 4/1.

Two other goalscoring options worth considering @ 9/4 are new signing Jonathan David and Julian Alvarez , who made a second-half appearance against Athletic after seeing his hopes of leaving this summer come to nothing.

4/7
● LIVE ODDS Yes Both Teams To Score

Betting Tips

Liverpool vs Atletico Madrid Betting Tips – Champions League 2026-27

Liverpool to win & BTTS @ 2/1

Alexander Isak to score at any time @ 11/10

Bradley Barcola to score at any time @ 15/8

BTTS @ 4/7

Simply click/tap on the above betting tips to add to your betslip.

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*Prices are subject to fluctuation

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